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Algorithm card · from Day 2

Laryngospasm

The patient cannot move air after extubation, and you have seconds rather than minutes.

Steps marked General recommendation are widely taught and are not verified against a primary source by this project; they carry no ledger entry. Follow your institution's protocol. Every other step cites the source it rests on.

Recognize

Stridor, paradoxical chest and abdominal movement, no air at the mouth, a falling saturation. It is often obvious, but not always: in the incident registry the presentation was clinically obvious in 77% of reports, airway obstruction in 14%, regurgitation or vomiting in 5%, and desaturation alone in 4% visvanathan-2005-laryngospasm.

Obstruction from the tongue looks the same from the end of the bed and is commoner in a recovering patient than spasm of the larynx visvanathan-2005-airway.

Act, in order

  1. Call for help. Give 100% oxygen. General recommendation. Remove the stimulus: suction blood and secretions, stop any airway manipulation, and take out an airway device the patient is fighting. Widely taught and not verified against a primary source by this project; it carries no ledger entry. Follow your institution's protocol.

  2. General recommendation. Jaw thrust with firm pressure in the laryngospasm notch behind the earlobe, the Larson maneuver, with chin lift; place an oral or nasal airway if the tongue is the obstruction. Widely taught and not verified against a primary source by this project; it carries no ledger entry. Follow your institution's protocol.

  3. General recommendation. Continuous positive airway pressure by a tight-fitting mask with the reservoir bag. Avoid vigorous positive pressure, which inflates the stomach and makes everything worse. Widely taught and not verified against a primary source by this project; it carries no ledger entry. Follow your institution's protocol.

  4. General recommendation. If it is not breaking, deepen anesthesia: propofol about 0.5 to 1 mg/kg intravenously in a patient with access. Widely taught and not verified against a primary source by this project; it carries no ledger entry. Follow your institution's protocol.

  5. General recommendation. If still obstructed or desaturating, succinylcholine. Doses commonly quoted are 0.1 to 0.5 mg/kg intravenously at low dose, or 1 to 1.5 mg/kg with intubation. No trial compares these sequences. Widely taught and not verified against a primary source by this project; it carries no ledger entry. Follow your institution's protocol. The label gives an average intravenous dose of 0.6 mg/kg to produce blockade and facilitate intubation, and for the intramuscular route up to 3 to 4 mg/kg not exceeding 150 mg in total, with onset usually in about 2 to 3 min fda-succinylcholine-label-2022.

  6. General recommendation. In a child, give atropine for the bradycardia that accompanies hypoxia and succinylcholine. Widely taught and not verified against a primary source by this project; it carries no ledger entry. Follow your institution's protocol. Bradycardia occurred in 6% of registry cases overall and in 23% of patients under one year visvanathan-2005-laryngospasm.

After it breaks

Do not treat resolution as the end. The registry names post-obstructive pulmonary edema, aspiration and severe hypoxemia as the morbidity of poorly managed laryngospasm visvanathan-2005-laryngospasm.

Watch for negative-pressure pulmonary edema: pink frothy sputum, hypoxemia, bilateral infiltrates. In a recovery-room series the precipitant was glossoptosis after extubation in four of five cases and laryngeal mask displacement in one, and none had a poor outcome bmc-nppe-2025. General recommendation. Treat it with oxygen and continuous positive airway pressure, and reintubate if the patient cannot maintain oxygenation; it usually settles within 12 to 24 hours. Widely taught and not verified against a primary source by this project; it carries no ledger entry. Follow your institution's protocol.

The registry authors judged that a structured approach would have brought earlier recognition or better management in 16% of their cases visvanathan-2005-laryngospasm.

Sources

[[visvanathan-2005-laryngospasm]] case series 2005 n: 189 laryngospasm incidents open era-limited

Visvanathan T, Kluger MT, Webb RK, Westhorpe RN. Crisis management during anaesthesia: laryngospasm. Qual Saf Health Care. 2005 Jun;14(3):e3.

189 reports of laryngospasm within the first 4000 incidents reported to the Australian Incident Monitoring Study; authors state that had a structured approach been used, earlier recognition or better management may have occurred in 16% of these cases; explicitly names post-obstructive pulmonary oedema, aspiration and severe hypoxaemia as the downstream morbidity of poorly managed laryngospasm

[[visvanathan-2005-airway]] case series 2005 n: UNVERIFIED open era-limited

Visvanathan T, Kluger MT, Webb RK, Westhorpe RN. Crisis management during anaesthesia: obstruction of the natural airway. Qual Saf Health Care. 2005 Jun;14(3):e2.

Companion AIMS analysis for obstruction of the natural airway; carries the observation that natural-airway obstruction may present simply as desaturation, which is the same-mechanism-different-timepoint framing the day rests on

[[fda-succinylcholine-label-2022]] advisory 2022 n: NA open

QUELICIN (succinylcholine chloride) Injection, USP [prescribing information]. Hospira, Inc. Revised 11/2022. DailyMed set ID fb08161e-7711-406d-e7b3-ea4515c07983.

FDA label. IV: 'The average dose required to produce neuromuscular blockade and to facilitate tracheal intubation is 0.6 mg/kg.' IM: 'up to 3 mg/kg to 4 mg/kg to infants, older pediatric patients, or adults. The total dose administered by the intramuscular route should not exceed 150 mg.' IM onset 'usually observed in about 2 to 3 minutes.' Boxed warning: hyperkalemic rhabdomyolysis/cardiac arrest in children with undiagnosed myopathy (Duchenne). Label carries no laryngospasm-specific dose.

[[bmc-nppe-2025]] case series 2025 n: 5 open

Negative pressure pulmonary edema resulting from upper airway obstruction during the post-anesthesia recovery period: a case series and literature review. BMC Anesthesiol. 2025. (author list UNVERIFIED)

Five NPPE cases during recovery from general anaesthesia at one institution: four attributed to glossoptosis after extubation, one to laryngeal mask displacement; all had typical clinical and imaging features; none had a poor outcome. Carries the point that the precipitant in the recovery period is not always laryngospasm.